If Spore freezes on the splash screen when you start it up, with one running process and one non-responding one, then all you have to do is*:

1. Browse to the SPORE application in Finder
2. Right-click the spore application and select “Show Package Contents”
3. In the new finder window browser into the the MacOS directory and move the “cider_noui” file away to another location, like your desktop.
4. Launch Spore again and keep your fingers crossed.

I found this piece of information through MacRumors.

* I do not take any responsibility for any damage these steps may cause. You follow them at your own risk and understanding that they may cause further issues and that they not work in all circumstances.